Sedating effects of dating frequency new relationship
Interested individuals were scheduled for a screening visit, during which we determined eligibility by obtaining a medical history, performing a focused physical examination, and obtaining written informed consent.
To address these clinically important concerns, we designed a prospective randomized study in healthy volunteers.
We did not design a placebo control because this study was a repeated measures trial where participants acted as their own control.
We also felt that participants would easily be able to identify whether they did not receive an active intravenous sedative drug.
These recovery characteristics have been well studied.22–24 The rest periods in-between pain modalities were 3 to 5 min and the rest period from baseline to sedation testing was at least 30 min.
This experimental design was constructed such that both habituation and sensitization were avoided.